Kreon TRAVIX

Pancreatin helps digest food. Enzymes are obtained from pork pancreas. Kreon Travix contains small granules that slowly release pancreatin in the intestine (stomach acid resistant granules called minimicrospheres).

The enzymes in the drug work by digesting food that passes through the small intestine. Treatment with Kreon Travix significantly reduces the severity of the symptoms of exocrine pancreatic insufficiency, including abdominal pain, flatulence, regulates the frequency of bowel movements, and improves the consistency of stools, regardless of the underlying disease. Kreon Travix should be taken with or after main meals or snacks. This will allow the enzymes to mix thoroughly with the food.

Indications

Creon Travix is ​​used in children, adolescents and adults with digestive disorders due to exocrine pancreatic insufficiency. This is a disease in which the pancreas does not produce enough of the enzymes to digest food. This disease often occurs in patients with the following diseases:
• cystic fibrosis (a rare genetic disease)
• Blockage of the ducts leading out of the pancreas or gallbladder
• an attack of acute pancreatitis. You can start taking this medicine while you are still taking this medicine
will resume oral food intake
• chronic pancreatitis
• cancer of the pancreas
• a removed pancreas or part of it
• a removed stomach or part of it
• gastrointestinal anastomosis
• Shwachman-Diamond syndrome (a very rare genetic disease).

Pancreatic exocrine insufficiency can also be diagnosed in other clinical conditions not mentioned above.

Contraindications

Do not take Creon Travix:

• if you are allergic to pork pancreatin or any of the other ingredients of this medicine.

Check with your doctor or pharmacist if you are unsure.

Warnings and Precautions

A rare disease of the large intestine called fibrosing colonopathy, in which the large intestine becomes narrow, has been reported in patients with cystic fibrosis who have taken high doses of pancreatin.

Therefore, in the case of cystic fibrosis and taking pancreatin in a dose greater than 10,000 units of Ph. Eur. lipase / kg body weight / day and if you experience any disturbing symptoms from the digestive system or changes in the current symptoms, contact your doctor.

Pregnancy

• If you are pregnant or suspect that you are pregnant, consult your doctor before taking Creon Travix. Your doctor will decide if you can take the drug and in what dose.

• This medicine can be used during breast-feeding.

Dosage

Always take this medicine exactly as your doctor or pharmacist has told you. Check with your doctor or pharmacist if you are not sure.

Dosage of Kreon Travix
• The dose is measured in lipase units. Lipase is one of the enzymes of pancreatin.
Different strengths of Creon contain different amounts of lipase.
• The doctor decides about the number of capsules to be taken.
• Your doctor will adjust the dose to your needs. It depends on:
- the type of disease
- body weight
- diet used
- the amount of fat present in the stool.
• If fatty stools or stomach or intestinal problems (gastrointestinal symptoms) persist, contact your doctor as the dose may need to be adjusted.

Cystic fibrosis
• The usual starting dose for children under 4 years of age is 1000 lipase units / kg body weight / meal.
• The usual starting dose for children 4 years of age and older, adolescents and adults is 500 lipase units / kg body weight / meal.
• In most patients, the dose should be lower or less than 10,000 lipase units / kg body weight / day or 4,000 lipase units / g fat ingested.

Other pancreatic disorders - adults
• The usual dose is 25,000 to 80,000 lipase units (2 to 8 capsules) for each main meal (breakfast, lunch, dinner).
• For snacks, the usual dose is half the dose taken with the main meal (1 to 4 capsules).

When to take the drug

Kreon Travix should always be taken with or shortly after main meals and snacks.

This will allow the enzymes to mix thoroughly with the food and digest as they pass through the small intestine.

How to take the drug
• Swallow the capsules whole.
• The capsules must not be bitten or chewed.
• If the capsules are difficult to swallow, you can carefully open them and add the granules to soft acidic food or mix them with an acidic drink. The acidic food can be, for example, applesauce or yoghurt. The acidic drink can be apple, orange or pineapple juice.
• Swallow the mixture immediately without chewing or chewing and drink some water or juice.
• Mixing with non-acidic food or drink, biting or chewing the mini-microspheres may cause irritation of the mouth or change the effect of Creon Travix.